Therapy Detail
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| Therapy Name | Pegylated liposomal doxorubicin + Vincristine Sulfate |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Pegylated liposomal doxorubicin | Doxil | ATI-0918|CAELYX|liposomal doxorubicin | Chemotherapy - Anthracycline 13 | Doxil (pegylated liposomal doxorubicin) comprises the anthracyline doxorubicin, which intercalates into DNA and disrupts DNA replication, encapsulated in a liposome, which improves tumor penetration and decreases toxicity (NCI Drug Dictionary), and is FDA approved for ovarian cancer, AIDS-related Kaposi's sarcoma, and multiple myeloma (FDA.gov). |
| Vincristine Sulfate | Oncovin | 22-Oxovincaleukoblastine|vincristine | Oncovin (vincristine) binds microtubules and prevents mitotic spindle formation, resulting in cell-cycle arrest (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07194044 | Phase I | Cyclophosphamide + Topotecan Ifosfamide Cyclophosphamide + Doxorubicin + Vincristine Sulfate Cyclophosphamide + Etoposide Dactinomycin + Ifosfamide + Irinotecan + Vincristine Sulfate Cabozantinib Irinotecan + Temozolomide Pegylated liposomal doxorubicin + Vincristine Sulfate | Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes (METTSEO) | Recruiting | USA | 0 |
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