Dargistotug
Drug Detail
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| Drug Name | Dargistotug |
| Trade Name | |
| Synonyms | M-6223|M 6223|M6223 |
| Drug Descriptions |
Dargistotug (M6223) targets and binds to TIGIT on immune cells, including tumor-infiltrating lymphocytes, and prevents its interaction with CD112 and CD155, thereby leading to enhanced interaction of CD112 and CD155 with CD226 expressed on natural killer and CD8 T+ cells, which may lead to the activation of anti-tumor immune responses (NCI Drug Dictionary). |
| DrugClasses | TIGIT Antibody 21 |
| CAS Registry Number | 2649362-29-6 |
| NCIT ID | C173891 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Avelumab + Dargistotug | Avelumab Dargistotug | 0 | 1 |
| Bintrafusp alfa + Dargistotug | Bintrafusp alfa Dargistotug | 0 | 1 |
| Dargistotug | Dargistotug | 0 | 1 |
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