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Drug Name PC14586
Trade Name
Synonyms PC 14586|PC-14586|Rezatapopt
Drug Descriptions

PC14586 is a small molecule that stabilizes TP53 Y220C and reactivates TP53 function, which may lead to cell cycle arrest and growth inhibition (AACR Annual Meeting Apr 2021, Session MS.LBA01, Abstract # LB006).

DrugClasses p53 Activator 11
CAS Registry Number NA
NCIT ID C175961

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + PC14586 Azacitidine PC14586 0 1
Azacitidine + PC14586 + Venetoclax Azacitidine PC14586 Venetoclax 0 1
PC14586 PC14586 7 1
PC14586 + Pembrolizumab PC14586 Pembrolizumab 0 1


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