Rezatapopt
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| Drug Name | Rezatapopt |
| Trade Name | |
| Synonyms | PC 14586|PC-14586|PC14586 |
| Drug Descriptions |
Rezatapopt (PC14586) is a small molecule that stabilizes TP53 Y220C and reactivates TP53 function, which may lead to cell cycle arrest and growth inhibition (AACR Annual Meeting Apr 2021, Session MS.LBA01, Abstract # LB006). |
| DrugClasses | p53 Activator 12 |
| CAS Registry Number | NA |
| NCIT ID | C175961 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Azacitidine + Rezatapopt | Azacitidine Rezatapopt | 0 | 1 |
| Azacitidine + Rezatapopt + Venetoclax | Azacitidine Rezatapopt Venetoclax | 0 | 1 |
| Metformin + Rezatapopt + Rosuvastatin | Metformin Rezatapopt Rosuvastatin | 0 | 0 |
| Midazolam + Repaglinide + Rezatapopt | Midazolam Repaglinide Rezatapopt | 0 | 0 |
| Pembrolizumab + Rezatapopt | Pembrolizumab Rezatapopt | 0 | 1 |
| Rezatapopt | Rezatapopt | 22 | 2 |
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