PC14586
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| Drug Name | PC14586 |
| Trade Name | |
| Synonyms | PC 14586|PC-14586|Rezatapopt |
| Drug Descriptions |
PC14586 is a small molecule that stabilizes TP53 Y220C and reactivates TP53 function, which may lead to cell cycle arrest and growth inhibition (AACR Annual Meeting Apr 2021, Session MS.LBA01, Abstract # LB006). |
| DrugClasses | p53 Activator 12 |
| CAS Registry Number | NA |
| NCIT ID | C175961 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Azacitidine + PC14586 | Azacitidine PC14586 | 0 | 1 |
| Azacitidine + PC14586 + Venetoclax | Azacitidine PC14586 Venetoclax | 0 | 1 |
| PC14586 | PC14586 | 7 | 1 |
| PC14586 + Pembrolizumab | PC14586 Pembrolizumab | 0 | 1 |
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