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Drug Name Metformin
Trade Name Glucophage
Synonyms Apo-Metformin
Drug Descriptions

Glucophage (metformin) inhibits part of the mitochondrial respiratory chain and may exert antineoplastic effects through inhibition of mTOR and is FDA approved for type 2 diabetes (FDA.gov).

DrugClasses mTOR Inhibitor 51
CAS Registry Number 657-24-9
NCIT ID C29251

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Letrozole + Metformin Abemaciclib Letrozole Metformin 0 1
Afatinib + Metformin Afatinib Metformin 0 0
AGI-5198 + Metformin AGI-5198 Metformin 1 0
Aldoxorubicin + Metformin Aldoxorubicin Metformin 0 0
Alpelisib + Dapagliflozin + Fulvestrant + Metformin Alpelisib Dapagliflozin Fulvestrant Metformin 0 1
Alpelisib + Fulvestrant + Metformin Alpelisib Fulvestrant Metformin 0 2
Atorvastatin + Metformin Atorvastatin Metformin 0 2
Bemcentinib + Metformin Bemcentinib Metformin 0 0
BI2536 + Metformin BI2536 Metformin 0 0
Bortezomib + Metformin + Nelfinavir Bortezomib Metformin Nelfinavir 0 1
Capecitabine + Cisplatin + Epirubicin + Gemcitabine + Metformin Capecitabine Cisplatin Epirubicin Gemcitabine Metformin 0 0
Carboplatin + Docetaxel + Metformin + Pertuzumab + Trastuzumab Carboplatin Docetaxel Metformin Pertuzumab Trastuzumab 0 1
Carboplatin + Metformin + Paclitaxel Carboplatin Metformin Paclitaxel 0 2
Carboplatin + Metformin + Pembrolizumab + Pemetrexed Disodium Carboplatin Metformin Pembrolizumab Pemetrexed Disodium 0 1
Carboplatin + Metformin + Pemetrexed Disodium Carboplatin Metformin Pemetrexed Disodium 0 0
Cisplatin + Gemcitabine + Metformin Cisplatin Gemcitabine Metformin 0 0
Cisplatin + Metformin Cisplatin Metformin 0 2
Cisplatin + Metformin + Pembrolizumab + Pemetrexed Disodium Cisplatin Metformin Pembrolizumab Pemetrexed Disodium 0 1
CPI-613 + Metformin CPI-613 Metformin 0 1
Cytarabine + Metformin Cytarabine Metformin 0 1
Cytarabine + Metformin + Venetoclax Cytarabine Metformin Venetoclax 0 1
Dabrafenib + Metformin + Trametinib Dabrafenib Metformin Trametinib 0 1
Dasatinib + Hydroxychloroquine + Metformin + Nelfinavir + Sirolimus Dasatinib Hydroxychloroquine Metformin Nelfinavir Sirolimus 0 1
Dasatinib + Hydroxychloroquine + Metformin + Sirolimus Dasatinib Hydroxychloroquine Metformin Sirolimus 0 1
Digoxin + Metformin + Simvastatin Digoxin Metformin Simvastatin 0 1
Doxycycline + Metformin Doxycycline Metformin 0 2
Durvalumab + Metformin Durvalumab Metformin 0 1
Enzalutamide + Metformin Enzalutamide Metformin 0 1
Erlotinib + Metformin Erlotinib Metformin 0 1
Everolimus + Letrozole + Metformin Everolimus Letrozole Metformin 0 0
Everolimus + Metformin Everolimus Metformin 0 0
GDC-0084 + Metformin GDC-0084 Metformin 0 1
Gefitinib + Metformin Gefitinib Metformin 0 0
Gemcitabine + Metformin + Nab-paclitaxel Gemcitabine Metformin Nab-paclitaxel 0 1
Gilteritinib + Metformin Gilteritinib Metformin 1 0
Hydroxychloroquine + Metformin + Nelfinavir + Sirolimus Hydroxychloroquine Metformin Nelfinavir Sirolimus 0 1
Hydroxychloroquine + Metformin + Sirolimus Hydroxychloroquine Metformin Sirolimus 0 1
JPH203 + Metformin JPH203 Metformin 0 0
Lapatinib + Metformin Lapatinib Metformin 0 1
Mefloquine + Memantine + Metformin + Temozolomide Mefloquine Memantine Metformin Temozolomide 0 1
Mefloquine + Metformin + Temozolomide Mefloquine Metformin Temozolomide 0 1
Memantine + Metformin + Temozolomide Memantine Metformin Temozolomide 0 1
Metformin Metformin 7 53
Metformin + Nelfinavir Metformin Nelfinavir 0 1
Metformin + Nivolumab Metformin Nivolumab 0 3
Metformin + OPC Metformin OPC 0 2
Metformin + Pembrolizumab Metformin Pembrolizumab 0 3
Metformin + Ritonavir Metformin Ritonavir 0 1
Metformin + Sapanisertib Metformin Sapanisertib 0 1
Metformin + Simvastatin Metformin Simvastatin 0 2
Metformin + Sirolimus Metformin Sirolimus 0 2
Metformin + Sorafenib Metformin Sorafenib 0 0
Metformin + Temozolomide Metformin Temozolomide 0 3
Metformin + Temsirolimus Metformin Temsirolimus 0 1
Metformin + Trametinib Metformin Trametinib 1 0
Metformin + Vandetanib Metformin Vandetanib 0 1
Metformin + Vemurafenib Metformin Vemurafenib 0 1
Metformin + Vismodegib Metformin Vismodegib 0 0


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