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| Drug Name | Trastuzumab rezetecan |
| Trade Name | |
| Synonyms | SHR A1811|SHRA1811|SHR-A1811 |
| Drug Descriptions |
Trastuzumab rezetecan (SHR-A1811) is an antibody-drug conjugate (ADC) comprising an ERBB2 (HER2)-targeting antibody linked to the camptothecin derivative rezetecan, which potentially induces DNA damage and apoptosis in ERBB2 (HER2)-expressing tumor cells and inhibits tumor growth (NCI Drug Dictionary, Cancer Res (2023) 83 (8_Supplement): LB031). |
| DrugClasses | HER2 (ERBB2) Antibody 79 HER2 (ERBB2) Antibody-Drug Conjugate 35 |
| CAS Registry Number | 2647845-11-0 |
| NCIT ID | C178312 |
| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Carboplatin + Nab-paclitaxel + Pertuzumab + Trastuzumab + Trastuzumab rezetecan | Carboplatin Nab-paclitaxel Pertuzumab Trastuzumab Trastuzumab rezetecan | 0 | 0 |
| Pyrotinib + Trastuzumab rezetecan | Pyrotinib Trastuzumab rezetecan | 0 | 0 |
| Trastuzumab rezetecan | Trastuzumab rezetecan | 0 | 1 |