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| Drug Name | Pertuzumab |
| Trade Name | Perjeta |
| Synonyms | 2C4 Antibody |
| Drug Descriptions |
Perjeta (pertuzumab) is a monoclonal antibody that binds ERBB2 (HER2) to prevent dimerization and subsequent HER signaling, thereby resulting in apoptosis and tumor growth inhibition (PMID: 15699478). Perjeta (pertuzumab) is FDA approved in combination with Herceptin (trastuzumab) and Taxotere (docetaxel) for patients with ERBB2 (HER2)-positive breast cancer and in combination with Herceptin (trastuzumab) and chemotherapy as neoadjuvant treatment for patients with ERBB2 (HER2)-positive breast cancer (FDA.gov). |
| DrugClasses | HER2 (ERBB2) Antibody 76 |
| CAS Registry Number | 380610-27-5 |
| NCIT ID | C38692 |
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