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Drug Detail
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| Drug Name | Cobicistat |
| Trade Name | Tybost |
| Synonyms | GS 9350|Evotaz|Genvoya|Prezcobix|Rezolsta|Stribild |
| Drug Descriptions |
Tybost (cobicistat) is an inhibitor of human cytochrome P450 3A (CYP3A), which potentially enhances exposure to other co-administered drugs (PMID: 24900196, PMID: 35933915). Tybost (cobicistat) is FDA approved to increase systemic exposure of atazanavir or darunavir in combination with other antiretroviral agents in the treatment of HIV-1 infection (FDA.gov). |
| DrugClasses | |
| CAS Registry Number | 1004316-88-4 |
| NCIT ID | C97360 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Cobicistat | Cobicistat | 0 | 0 |
| Cobicistat + Gemcitabine + Nab-paclitaxel | Cobicistat Gemcitabine Nab-paclitaxel | 0 | 1 |
| Cobicistat + Olaparib | Cobicistat Olaparib | 0 | 1 |
| Cobicistat + Osimertinib | Cobicistat Osimertinib | 0 | 0 |
| Cobicistat + PLX8394 | Cobicistat PLX8394 | 0 | 1 |
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