Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Drug Name PLX8394
Trade Name
Synonyms PLX 8394|PLX-8394|FORE8394|FORE-8394|FORE 8394|Plixorafenib
Drug Descriptions

PLX8394 is a RAF inhibitor that inhibits wild-type and mutant BRAF, as well as CRAF, and does not paradoxically activate MAPK signaling, potentially resulting in decreased proliferation of BRAF-mutant tumor cells (PMID: 26466569, PMID: 24283590, PMID: 28659148, PMID: 30559419).

DrugClasses BRAF Inhibitor 25 CRAF Inhibitor 12
CAS Registry Number 1393466-87-9
NCIT ID C113330

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Binimetinib + PLX8394 Binimetinib PLX8394 2 0
Cetuximab + PLX8394 Cetuximab PLX8394 2 0
Cobicistat + PLX8394 Cobicistat PLX8394 0 1
Everolimus + PLX8394 Everolimus PLX8394 0 0
JQ1 + PLX8394 JQ1 PLX8394 1 0
PLX8394 PLX8394 25 4


Additional content available in CKB BOOST