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Drug Name | PLX8394 |
Trade Name | |
Synonyms | PLX 8394|PLX-8394|FORE8394|FORE-8394|FORE 8394|Plixorafenib |
Drug Descriptions |
PLX8394 is a RAF inhibitor that inhibits wild-type and mutant BRAF, as well as CRAF, and does not paradoxically activate MAPK signaling, potentially resulting in decreased proliferation of BRAF-mutant tumor cells (PMID: 26466569, PMID: 24283590, PMID: 28659148, PMID: 30559419). |
DrugClasses | BRAF Inhibitor 25 CRAF Inhibitor 12 |
CAS Registry Number | 1393466-87-9 |
NCIT ID | C113330 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Binimetinib + PLX8394 | Binimetinib PLX8394 | 2 | 0 |
Cetuximab + PLX8394 | Cetuximab PLX8394 | 2 | 0 |
Cobicistat + PLX8394 | Cobicistat PLX8394 | 0 | 1 |
Everolimus + PLX8394 | Everolimus PLX8394 | 0 | 0 |
JQ1 + PLX8394 | JQ1 PLX8394 | 1 | 0 |
PLX8394 | PLX8394 | 25 | 4 |