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Drug Name Revumenib
Trade Name Revuforj
Synonyms SNDX5613|SNDX 5613|SNDX-5613
Drug Descriptions

Revuforj (revumenib) inhibits the interaction between Menin and KMT2A (MLL), potentially resulting in antitumor activity and decreased proliferation of tumor cells with KMT2A (MLL) rearrangements or NPM1 mutations (PMID: 36922593, PMID: 36922589). Revuforj (revumenib) is FDA-approved for use in adult and pediatric patients 1 year and older with relapsed or refractory acute leukemia harboring KMT2A translocation (FDA.gov).

DrugClasses MEN1-KMT2A Inhibitor 8
CAS Registry Number 2169919-21-3
NCIT ID C165776

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Revumenib + Venetoclax Azacitidine Revumenib Venetoclax 0 1
Cytarabine + Daunorubicin + Midostaurin + Revumenib Cytarabine Daunorubicin Midostaurin Revumenib 0 1
Cytarabine + Daunorubicin + Revumenib Cytarabine Daunorubicin Revumenib 0 2
Cytarabine + Idarubicin + Revumenib Cytarabine Idarubicin Revumenib 0 1
Cytarabine + Midostaurin + Revumenib Cytarabine Midostaurin Revumenib 0 1
FHD-286 + Revumenib FHD-286 Revumenib 1 0
Gilteritinib + Revumenib Gilteritinib Revumenib 0 1
Revumenib Revumenib 3 10
Revumenib + Venetoclax Revumenib Venetoclax 1 1


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