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Drug Name | AZD8421 |
Trade Name | |
Synonyms | AZD-8421|AZD 8421 |
Drug Descriptions |
AZD8421 selectively inhibits CDK2, potentially leading to decreased Rb1 phosphorylation, cell cycle arrest, and inhibition of proliferation and tumor growth (Cancer Res (2024) 84 (6_Supplement): 5730). |
DrugClasses | CDK2 Inhibitor 31 |
CAS Registry Number | NA |
NCIT ID | C204103 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Abemaciclib + AZD8421 + Camizestrant | AZD8421 Abemaciclib Camizestrant | 0 | 1 |
AZD8421 | AZD8421 | 0 | 1 |
AZD8421 + Camizestrant + Palbociclib | AZD8421 Camizestrant Palbociclib | 0 | 1 |
AZD8421 + Camizestrant + Ribociclib | AZD8421 Camizestrant Ribociclib | 0 | 1 |
AZD8421 + Palbociclib | AZD8421 Palbociclib | 0 | 0 |