Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Drug Name AZD8421
Trade Name
Synonyms AZD-8421|AZD 8421
Drug Descriptions

AZD8421 selectively inhibits CDK2, potentially leading to decreased Rb1 phosphorylation, cell cycle arrest, and inhibition of proliferation and tumor growth (Cancer Res (2024) 84 (6_Supplement): 5730).

DrugClasses CDK2 Inhibitor 31
CAS Registry Number NA
NCIT ID C204103

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + AZD8421 + Camizestrant AZD8421 Abemaciclib Camizestrant 0 1
AZD8421 AZD8421 0 1
AZD8421 + Camizestrant + Palbociclib AZD8421 Camizestrant Palbociclib 0 1
AZD8421 + Camizestrant + Ribociclib AZD8421 Camizestrant Ribociclib 0 1
AZD8421 + Palbociclib AZD8421 Palbociclib 0 0


Additional content available in CKB BOOST