Danusertib
Drug Detail
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| Drug Name | Danusertib |
| Trade Name | |
| Synonyms | PHA-739358 |
| Drug Descriptions |
Danusertib (PHA-739358) is a pan-Aurora kinase with additional activity against ABL, FGFR1, RET, TRKA, and BCR-ABL, including the T315I mutant (PMID: 20072840, PMID: 18089710, PMID: 31625025). |
| DrugClasses | ABL1 Inhibitor 8 AURK Inhibitor (Pan) 12 BCR-ABL Inhibitor 32 FGFR1 Inhibitor 28 RET Inhibitor 53 TrkA Receptor Inhibitor 8 |
| CAS Registry Number | 827318-97-8 |
| NCIT ID | C61587 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Danusertib | Danusertib | 1 | 0 |
| Danusertib + Fulvestrant | Danusertib Fulvestrant | 0 | 0 |
| Danusertib + Palbociclib | Danusertib Palbociclib | 2 | 0 |
| Danusertib + SCH772984 | Danusertib SCH772984 | 0 | 0 |
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