Uprosertib
Drug Detail
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| Drug Name | Uprosertib |
| Trade Name | |
| Synonyms | GSK2141795|GSK-2141795|GSK 2141795 |
| Drug Descriptions |
Uprosertib (GSK2141795) is an ATP-competitive inhibitor of AKT, which leads to inhibition of PI3K/AKT signaling potentially resulting in inhibition of cell proliferation and anti-tumor growth (PMID: 24978597, PMID: 32062691). |
| DrugClasses | Akt Inhibitor (Pan) 22 AKT Inhibitor (Pan) - ATP competitive 7 |
| CAS Registry Number | 1047634-65-0 |
| NCIT ID | C84870 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Cisplatin + Uprosertib | Cisplatin Uprosertib | 0 | 0 |
| Dabrafenib + Trametinib + Uprosertib | Dabrafenib Trametinib Uprosertib | 0 | 1 |
| Dabrafenib + Uprosertib | Dabrafenib Uprosertib | 0 | 1 |
| Tipifarnib + Uprosertib | Tipifarnib Uprosertib | 1 | 0 |
| Trametinib + Uprosertib | Trametinib Uprosertib | 0 | 8 |
| Uprosertib | Uprosertib | 2 | 0 |
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