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Drug Name | Tipifarnib |
Trade Name | |
Synonyms | Zarnestra|R115777 |
Drug Descriptions |
Zarnestra (tipifarnib) is a farnesyltransferase inhibitor, which alters post-translational modification and activation of Ras proteins, and may result in decreased tumor cell proliferation and reduced tumor growth (PMID: 11196150, PMID: 25323927, PMID: 32557577). |
DrugClasses | Farnesyltransferase Inhibitor 4 |
CAS Registry Number | 192185-72-1 |
NCIT ID | C1703 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Adagrasib + Tipifarnib | Adagrasib Tipifarnib | 0 | 0 |
Alpelisib + Tipifarnib | Alpelisib Tipifarnib | 11 | 1 |
AZD8186 + Tipifarnib | AZD8186 Tipifarnib | 0 | 0 |
Naxitamab + Tipifarnib | Naxitamab Tipifarnib | 0 | 1 |
Osimertinib + Tipifarnib | Osimertinib Tipifarnib | 0 | 1 |
Pictilisib + Tipifarnib | Pictilisib Tipifarnib | 0 | 0 |
Sapanisertib + Tipifarnib | Sapanisertib Tipifarnib | 1 | 0 |
SCH772984 + Tipifarnib | SCH772984 Tipifarnib | 2 | 0 |
Sotorasib + Tipifarnib | Sotorasib Tipifarnib | 0 | 0 |
Tipifarnib | Tipifarnib | 25 | 8 |
Tipifarnib + Trametinib | Tipifarnib Trametinib | 2 | 0 |
Tipifarnib + Ulixertinib | Tipifarnib Ulixertinib | 2 | 0 |
Tipifarnib + Uprosertib | Tipifarnib Uprosertib | 1 | 0 |