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Drug Name Perifosine
Trade Name
Synonyms KRX-0401|NSC-639966
Drug Descriptions

Perifosine (KRX-0401) is a synthetic alkylphospholipid that inhibits AKT resulting in apoptotic induction and antitumor activity (PMID: 16418332, PMID: 28864978, PMID: 31325145).

DrugClasses Akt Inhibitor (Pan) 21
CAS Registry Number 157716-52-4
NCIT ID C1727

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Therapy Name Drugs Efficacy Evidence Clinical Trials
ABT-737 + Perifosine ABT-737 Perifosine 0 0
Cisplatin + Perifosine Cisplatin Perifosine 0 0
Gefitinib + Perifosine Gefitinib Perifosine 0 0
Lapatinib + Perifosine Lapatinib Perifosine 0 0
Perifosine Perifosine 3 1
Perifosine + Temsirolimus Perifosine Temsirolimus 0 1


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