AZ628
Drug Detail
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| Drug Name | AZ628 |
| Trade Name | |
| Synonyms | AZD628|AZD-628 |
| Drug Descriptions |
AZ628 is an irreversible pan-RAF inhibitor with activity against RAF1 and BRAF, including BRAF V600E, which leads to increased cell-cycle arrest and apoptosis of tumor cells (PMID: 18020980, PMID: 23288408). |
| DrugClasses | RAF Inhibitor (Pan) 29 |
| CAS Registry Number | 878739-06-1 |
| NCIT ID | NA |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| AZ628 | AZ628 | 9 | 0 |
| AZ628 + CPI-455 | AZ628 CPI-455 | 0 | 0 |
| AZ628 + Selumetinib | AZ628 Selumetinib | 1 | 0 |
| AZ628 + Trametinib | AZ628 Trametinib | 0 | 0 |
| AZ628 + VX-11e | AZ628 VX-11e | 0 | 0 |
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