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Drug Name | FANG vaccine |
Trade Name | |
Synonyms | Vigil|bi-shRNA-furin/GMCSF-expressing autologous tumor cell vaccine |
Drug Descriptions |
Vigil (FANG vaccine) is a combination of autologous tumor cells expressing recombinant human granulocyte macrophage-colony stimulating factor (GM-CSF) and RNAi against furin convertase. FANG stimulates cell maturation through GM-CSF and prevents GM-CSF degradation by Tgfb1 and Tgfb2 (PMID: 22186789). |
DrugClasses | |
CAS Registry Number | NA |
NCIT ID | C90552 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Atezolizumab + FANG vaccine | Atezolizumab FANG vaccine | 0 | 1 |
Bevacizumab + FANG vaccine | Bevacizumab FANG vaccine | 0 | 1 |
Durvalumab + FANG vaccine | Durvalumab FANG vaccine | 0 | 1 |
FANG vaccine | FANG vaccine | 0 | 4 |
FANG vaccine + Irinotecan + Temozolomide | FANG vaccine Irinotecan Temozolomide | 0 | 2 |
FANG vaccine + Nivolumab | FANG vaccine Nivolumab | 0 | 1 |