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Drug Name | LGK974 |
Trade Name | |
Synonyms | WNT974|WNT-974 |
Drug Descriptions |
LGK974 (WNT-974) binds to and inhibits porcupine (PORCN), resulting in decreased secretion of Wnt ligands and concomitant decrease in Wnt signaling, potentially resulting in reduced cell growth in tumors with dysregulated Wnt signaling (PMID: 32104684). |
DrugClasses | WNT Inhibitor 16 |
CAS Registry Number | 1243244-14-5 |
NCIT ID | C116860 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Cetuximab + Encorafenib + LGK974 | Cetuximab Encorafenib LGK974 | 0 | 1 |
LGK974 | LGK974 | 0 | 2 |
LGK974 + Spartalizumab | LGK974 Spartalizumab | 0 | 1 |