SAR405838
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| Drug Name | SAR405838 |
| Trade Name | |
| Synonyms | MI-77301|MI-773|MI773|SAR-405838 |
| Drug Descriptions |
SAR405838 (MI-77301) binds to MDM2 and inhibits MDM2-p53 interaction, resulting in activation of wild-type p53 signaling and decreased tumor growth (PMID: 25145672, PMID: 30585255, PMID: 31619389). |
| DrugClasses | MDM2 Inhibitor 23 |
| CAS Registry Number | 1303607-60-4 |
| NCIT ID | C106120 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Cisplatin + SAR405838 | Cisplatin SAR405838 | 1 | 0 |
| Doxorubicin + SAR405838 | Doxorubicin SAR405838 | 1 | 0 |
| Fulvestrant + SAR405838 | Fulvestrant SAR405838 | 0 | 0 |
| Pimasertib + SAR405838 | Pimasertib SAR405838 | 2 | 0 |
| SAR405838 | SAR405838 | 5 | 1 |
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