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Drug Name | SAR405838 |
Trade Name | |
Synonyms | MI-77301|MI-773|MI773|SAR-405838 |
Drug Descriptions |
SAR405838 (MI-77301) binds to MDM2 and inhibits MDM2-p53 interaction, resulting in activation of wild-type p53 signaling and decreased tumor growth (PMID: 25145672, PMID: 30585255, PMID: 31619389). |
DrugClasses | MDM2 Inhibitor 23 |
CAS Registry Number | 1303607-60-4 |
NCIT ID | C106120 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Cisplatin + SAR405838 | Cisplatin SAR405838 | 1 | 0 |
Doxorubicin + SAR405838 | Doxorubicin SAR405838 | 1 | 0 |
Fulvestrant + SAR405838 | Fulvestrant SAR405838 | 0 | 0 |
Pimasertib + SAR405838 | Pimasertib SAR405838 | 2 | 0 |
SAR405838 | SAR405838 | 5 | 1 |