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Drug Name | Siltuximab |
Trade Name | Sylvant |
Synonyms | CNTO 328|CNTO328 |
Drug Descriptions |
Sylvant (siltuxmab) is an anti-IL-6 chimeric monoclonal antibody, which inhibits IL6 signaling and may lead to decreased tumor cell growth (PMID: 26170629, PMID: 26744529). Sylvant (siltuximab) is FDA approved for patients with multicentric Castleman's disease who do not have HIV or HHV-8 (FDA.gov). |
DrugClasses | |
CAS Registry Number | 541502-14-1 |
NCIT ID | C61084 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Melphalan + Siltuximab | Melphalan Siltuximab | 0 | 1 |
Siltuximab | Siltuximab | 0 | 5 |
Siltuximab + Spartalizumab | Siltuximab Spartalizumab | 0 | 1 |