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Drug Name Melphalan
Trade Name Alkeran
Synonyms
Drug Descriptions

Alkeran (melphalan) is an antineoplastic alkylating agent, which cross-links DNA and induces cell toxicity and is FDA approved for multiple myeloma and epithelial ovarian carcinoma (FDA.gov).

DrugClasses Chemotherapy - Alkylating 18
CAS Registry Number 3223-07-2
NCIT ID C48002

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Aldesleukin + Melphalan + Sargramostim Aldesleukin Melphalan Sargramostim 0 1
Alemtuzumab + Fludarabine + Melphalan Alemtuzumab Fludarabine Melphalan 0 1
anti-thymocyte globulin + Cyclophosphamide + Filgrastim + Fludarabine + Melphalan + Mesna + Thiotepa Cyclophosphamide Filgrastim Fludarabine Melphalan Mesna Thiotepa anti-thymocyte globulin 0 1
anti-thymocyte globulin + Fludarabine + haNK cells + Melphalan Fludarabine Melphalan anti-thymocyte globulin haNK cells 0 1
anti-thymocyte globulin + Fludarabine + Melphalan Fludarabine Melphalan anti-thymocyte globulin 0 1
Basiliximab + Carmustine + Cytarabine + Etoposide + Melphalan + Yttrium Y 90 Basiliximab Basiliximab Carmustine Cytarabine Etoposide Melphalan Yttrium Y 90 Basiliximab 0 1
Bendamustine + Melphalan + Rituximab Bendamustine Melphalan Rituximab 0 1
Bortezomib + Daratumumab + Dexamethasone + Melphalan + Prednisone Bortezomib Daratumumab Dexamethasone Melphalan Prednisone 0 1
Bortezomib + Daratumumab + Melphalan Bortezomib Daratumumab Melphalan 0 0
Bortezomib + Daratumumab + Melphalan + Prednisone Bortezomib Daratumumab Melphalan Prednisone 0 0
Bortezomib + Daratumumab and hyaluronidase-fihj + Melphalan + Prednisone Bortezomib Daratumumab and hyaluronidase-fihj Melphalan Prednisone 0 0
Bortezomib + Dexamethasone + Lenalidomide + Melphalan + Prednisone Bortezomib Dexamethasone Lenalidomide Melphalan Prednisone 0 1
Bortezomib + Dexamethasone + Melphalan + Thalidomide Bortezomib Dexamethasone Melphalan Thalidomide 0 2
Bortezomib + Fludarabine + Melphalan Bortezomib Fludarabine Melphalan 0 1
Bortezomib + Melphalan + Prednisone Bortezomib Melphalan Prednisone 0 1
Busulfan + CPX-351 + Fludarabine + Melphalan + Midostaurin Busulfan CPX-351 Fludarabine Melphalan Midostaurin 0 1
Busulfan + Filgrastim + Fludarabine + Melphalan + MGTA-456 + Mycophenolate mofetil + Tacrolimus Busulfan Filgrastim Fludarabine MGTA-456 Melphalan Mycophenolate mofetil Tacrolimus 0 1
Busulfan + Gemcitabine + Melphalan + Panobinostat Busulfan Gemcitabine Melphalan Panobinostat 0 1
Busulfan + Melphalan Busulfan Melphalan 0 11
Busulfan + Melphalan + Thiotepa Busulfan Melphalan Thiotepa 0 1
Carboplatin + Cyclophosphamide + Etoposide + Melphalan + Thiotepa Carboplatin Cyclophosphamide Etoposide Melphalan Thiotepa 0 1
Carboplatin + Etoposide + Melphalan Carboplatin Etoposide Melphalan 0 2
Carboplatin + Etoposide + Melphalan + Vincristine Sulfate Carboplatin Etoposide Melphalan Vincristine Sulfate 0 1
Carboplatin + Melphalan Carboplatin Melphalan 0 1
Carmustine + CCR5 shRNA/TRIM5a/TAR decoy-transduced CD34+ HPCs + Cytarabine + Etoposide + Melphalan CCR5 shRNA/TRIM5a/TAR decoy-transduced CD34+ HPCs Carmustine Cytarabine Etoposide Melphalan 0 1
Carmustine + Cytarabine + Etoposide + Filgrastim + Lenalidomide + Melphalan + Rituximab Carmustine Cytarabine Etoposide Filgrastim Lenalidomide Melphalan Rituximab 0 1
Carmustine + Cytarabine + Etoposide + Melphalan Carmustine Cytarabine Etoposide Melphalan 0 5
Carmustine + Cytarabine + Etoposide + Melphalan + Rituximab Carmustine Cytarabine Etoposide Melphalan Rituximab 0 1
Carmustine + Cytarabine + Etoposide + Melphalan + Venetoclax Carmustine Cytarabine Etoposide Melphalan Venetoclax 0 2
Carmustine + Cytarabine + Etoposide + Melphalan + Yttrium Y 90 Basiliximab Carmustine Cytarabine Etoposide Melphalan Yttrium Y 90 Basiliximab 0 1
CD45RA-depleted donor lymphocytes + Cyclophosphamide + Filgrastim + Fludarabine + Melphalan + Tacrolimus CD45RA-depleted donor lymphocytes Cyclophosphamide Filgrastim Fludarabine Melphalan Tacrolimus 0 0
Clofarabine + Melphalan Clofarabine Melphalan 0 1
Cyclophosphamide + Cytarabine + Daunorubicin + Etoposide + Fludarabine + Imatinib + Melphalan + Mercaptopurine + Methotrexate + Pegaspargase + Rituximab + Vincristine Sulfate Cyclophosphamide Cytarabine Daunorubicin Etoposide Fludarabine Imatinib Melphalan Mercaptopurine Methotrexate Pegaspargase Rituximab Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Daunorubicin + Etoposide + Fludarabine + Imatinib + Melphalan + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Sulfate Cyclophosphamide Cytarabine Daunorubicin Etoposide Fludarabine Imatinib Melphalan Mercaptopurine Methotrexate Pegaspargase Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Daunorubicin + Etoposide + Fludarabine + Melphalan + Mercaptopurine + Methotrexate + Nelarabine + Pegaspargase + Vincristine Sulfate Cyclophosphamide Cytarabine Daunorubicin Etoposide Fludarabine Melphalan Mercaptopurine Methotrexate Nelarabine Pegaspargase Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Daunorubicin + Etoposide + Fludarabine + Melphalan + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Sulfate Cyclophosphamide Cytarabine Daunorubicin Etoposide Fludarabine Melphalan Mercaptopurine Methotrexate Pegaspargase Vincristine Sulfate 0 1
Cyclophosphamide + Fludarabine + Melphalan + Sirolimus Cyclophosphamide Fludarabine Melphalan Sirolimus 0 1
Cyclophosphamide + Fludarabine + Melphalan + Tacrolimus Cyclophosphamide Fludarabine Melphalan Tacrolimus 0 1
Dactinomycin + Ipilimumab + Melphalan Dactinomycin Ipilimumab Melphalan 0 1
Dexamethasone + Melphalan + Selinexor Dexamethasone Melphalan Selinexor 0 1
Docetaxel + Gemcitabine + Melphalan Docetaxel Gemcitabine Melphalan 0 1
Elotuzumab + Melphalan + Nogapendekin alfa inbakicept Elotuzumab Melphalan Nogapendekin alfa inbakicept 0 1
Etoposide + Melphalan Etoposide Melphalan 0 1
Fludarabine + Inotuzumab ozogamicin + Melphalan + Tacrolimus Fludarabine Inotuzumab ozogamicin Melphalan Tacrolimus 0 1
Fludarabine + Lenalidomide + Melphalan Fludarabine Lenalidomide Melphalan 0 1
Fludarabine + Melphalan Fludarabine Melphalan 0 10
Ipilimumab + Melphalan + Nivolumab Ipilimumab Melphalan Nivolumab 0 2
Melphalan Melphalan 0 35
Melphalan + PVX-410 Melphalan PVX-410 0 1
Melphalan + Siltuximab Melphalan Siltuximab 0 1


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