Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Drug Name | TRX518 |
Trade Name | |
Synonyms | TRX-518|TRX 518 |
Drug Descriptions |
TRX518 is an activating monoclonal antibody to the glucocorticoid-induced tumor necrosis factor receptor, TNFRSF18 (GITR, CD357), that blocks GITR signaling, leading to activation of immune response (PMID: 31036879). |
DrugClasses | GITR Antibody 7 |
CAS Registry Number | NA |
NCIT ID | C95023 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Avelumab + Cyclophosphamide + TRX518 | Avelumab Cyclophosphamide TRX518 | 0 | 1 |
Gemcitabine + TRX518 | Gemcitabine TRX518 | 0 | 0 |
Nivolumab + TRX518 | Nivolumab TRX518 | 0 | 0 |
Pembrolizumab + TRX518 | Pembrolizumab TRX518 | 0 | 0 |
TRX518 | TRX518 | 0 | 2 |