TRX518
Drug Detail
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| Drug Name | TRX518 |
| Trade Name | |
| Synonyms | TRX-518|TRX 518 |
| Drug Descriptions |
TRX518 is an activating monoclonal antibody to the glucocorticoid-induced tumor necrosis factor receptor, TNFRSF18 (GITR, CD357), that blocks GITR signaling, leading to activation of immune response (PMID: 31036879). |
| DrugClasses | GITR Antibody 7 |
| CAS Registry Number | NA |
| NCIT ID | C95023 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Avelumab + Cyclophosphamide + TRX518 | Avelumab Cyclophosphamide TRX518 | 0 | 1 |
| Gemcitabine + TRX518 | Gemcitabine TRX518 | 0 | 0 |
| Nivolumab + TRX518 | Nivolumab TRX518 | 0 | 0 |
| Pembrolizumab + TRX518 | Pembrolizumab TRX518 | 0 | 0 |
| TRX518 | TRX518 | 0 | 2 |
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