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Drug Name | Plinabulin |
Trade Name | |
Synonyms | NPI-2358 |
Drug Descriptions |
Plinabulin (NPI-2358) is a diketopiperazine derivative that disrupts microtubule organization, leading to cell cycle arrest in tumor cells and collapse of tumor vasculature (PMID: 16317287, PMID: 31811421). |
DrugClasses | Antimicrotubule Agent 14 |
CAS Registry Number | 714272-27-2 |
NCIT ID | C62444 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Atezolizumab + Avelumab + Durvalumab + Nivolumab + Pembrolizumab + Plinabulin | Atezolizumab Avelumab Durvalumab Nivolumab Pembrolizumab Plinabulin | 0 | 1 |
Docetaxel + Plinabulin | Docetaxel Plinabulin | 0 | 1 |
Ipilimumab + Nivolumab + Plinabulin | Ipilimumab Nivolumab Plinabulin | 0 | 1 |
Nivolumab + Plinabulin | Nivolumab Plinabulin | 0 | 2 |
Plinabulin | Plinabulin | 0 | 2 |