Plinabulin
Drug Detail
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| Drug Name | Plinabulin |
| Trade Name | |
| Synonyms | NPI-2358 |
| Drug Descriptions |
Plinabulin (NPI-2358) is a diketopiperazine derivative that disrupts microtubule organization, leading to cell cycle arrest in tumor cells and collapse of tumor vasculature (PMID: 16317287, PMID: 31811421). |
| DrugClasses | Antimicrotubule Agent 14 |
| CAS Registry Number | 714272-27-2 |
| NCIT ID | C62444 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Atezolizumab + Avelumab + Durvalumab + Nivolumab + Pembrolizumab + Plinabulin | Atezolizumab Avelumab Durvalumab Nivolumab Pembrolizumab Plinabulin | 0 | 1 |
| Docetaxel + Plinabulin | Docetaxel Plinabulin | 0 | 1 |
| Ipilimumab + Nivolumab + Plinabulin | Ipilimumab Nivolumab Plinabulin | 0 | 1 |
| Nivolumab + Plinabulin | Nivolumab Plinabulin | 0 | 2 |
| Plinabulin | Plinabulin | 0 | 2 |
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