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Drug Name | INCB053914 |
Trade Name | |
Synonyms | INCB53914 |
Drug Descriptions |
INCB053914 is an ATP-competitive small molecule inhibitor of PIM kinases 1, 2, and 3, which may inhibit cell proliferation by blocking the phosphorylation of downstream targets (PMID: 29927999, PMID: 31725895). |
DrugClasses | PIM Inhibitor (Pan) 9 |
CAS Registry Number | 2088852-47-3 |
NCIT ID | C124226 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Cytarabine + INCB053914 | Cytarabine INCB053914 | 0 | 0 |
INCB053914 | INCB053914 | 3 | 1 |
INCB053914 + INCB054329 | INCB053914 INCB054329 | 0 | 0 |
INCB053914 + INCB057643 | INCB053914 INCB057643 | 0 | 0 |
INCB053914 + Itacitinib | INCB053914 Itacitinib | 0 | 0 |
INCB053914 + Parsaclisib | INCB053914 Parsaclisib | 0 | 1 |