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Therapy Name | INCB053914 |
Synonyms | |
Therapy Description |
INCB053914 is an ATP-competitive small molecule inhibitor of PIM kinases 1, 2, and 3, which may inhibit cell proliferation by blocking the phosphorylation of downstream targets (PMID: 29927999, PMID: 31725895). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
INCB053914 | INCB53914 | PIM Inhibitor (Pan) 9 | INCB053914 is an ATP-competitive small molecule inhibitor of PIM kinases 1, 2, and 3, which may inhibit cell proliferation by blocking the phosphorylation of downstream targets (PMID: 29927999, PMID: 31725895). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
JAK2 V617F | myelofibrosis | predicted - sensitive | INCB053914 | Preclinical - Patient cell culture | Actionable | In a preclinical study, INCB053914 inhibited erythroid colony formation in cells derived from patients with myeloproliferative neoplasms (MPNs), including primary myelofibrosis, harboring JAK2 V617F in culture (PMID: 29927999). | 29927999 |
JAK2 V617F | polycythemia vera | predicted - sensitive | INCB053914 | Preclinical - Patient cell culture | Actionable | In a preclinical study, INCB053914 inhibited erythroid colony formation in cells derived from patients with myeloproliferative neoplasms, including polycythemia vera, harboring JAK2 V617F in culture (PMID: 29927999). | 29927999 |
JAK2 V617F | essential thrombocythemia | predicted - sensitive | INCB053914 | Preclinical - Patient cell culture | Actionable | In a preclinical study, INCB053914 inhibited erythroid colony formation in cells derived from patient with myeloproliferative neoplasms (MPNs), including essential thrombocythemia, harboring JAK2 V617F in culture (PMID: 29927999). | 29927999 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT02587598 | Phase Ib/II | INCB053914 | Study of INCB053914 in Subjects With Advanced Malignancies | Terminated | USA | 0 |