Pepinemab
Drug Detail
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| Drug Name | Pepinemab |
| Trade Name | |
| Synonyms | VX15/2503 |
| Drug Descriptions |
Pepinemab (VX15/2503) is a monoclonal antibody that binds to semaphorin 4D (SEMA4D) and blocks plexin-B1 binding, leading to anti-tumor and immune regulatory activity (PMID: 26446947, PMID: 28642891). |
| DrugClasses | |
| CAS Registry Number | 2097151-87-4 |
| NCIT ID | C96222 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Avelumab + Pepinemab | Avelumab Pepinemab | 0 | 2 |
| Ipilimumab + Nivolumab + Pepinemab | Ipilimumab Nivolumab Pepinemab | 0 | 1 |
| Ipilimumab + Pepinemab | Ipilimumab Pepinemab | 0 | 4 |
| Nivolumab + Pepinemab | Nivolumab Pepinemab | 0 | 4 |
| Pembrolizumab + Pepinemab | Pembrolizumab Pepinemab | 0 | 1 |
| Pepinemab | Pepinemab | 0 | 4 |
| Pepinemab + Trastuzumab | Pepinemab Trastuzumab | 0 | 1 |
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