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Drug Name | CHZ868 |
Trade Name | |
Synonyms | |
Drug Descriptions |
CHZ868 is a type II JAK2 inhibitor, which stabilizes JAK2 in the inactive conformation resulting in decreased downstream signaling and potentially leading to decreased tumor cell growth (PMID: 26175413, PMID: 30498775). |
DrugClasses | JAK2 Inhibitor 19 |
CAS Registry Number | 1895895-38-1 |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Binimetinib + CHZ868 | Binimetinib CHZ868 | 1 | 0 |
CHZ868 | CHZ868 | 5 | 0 |