CHZ868
Drug Detail
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| Drug Name | CHZ868 |
| Trade Name | |
| Synonyms | |
| Drug Descriptions |
CHZ868 is a type II JAK2 inhibitor, which stabilizes JAK2 in the inactive conformation resulting in decreased downstream signaling and potentially leading to decreased tumor cell growth (PMID: 26175413, PMID: 30498775). |
| DrugClasses | JAK2 Inhibitor 19 |
| CAS Registry Number | 1895895-38-1 |
| NCIT ID | NA |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Binimetinib + CHZ868 | Binimetinib CHZ868 | 1 | 0 |
| CHZ868 | CHZ868 | 11 | 0 |
| CHZ868 + Dexamethasone | CHZ868 Dexamethasone | 0 | 0 |
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