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| Drug Name | Zolbetuximab |
| Trade Name | Vyloy |
| Synonyms | IMAB362|Claudiximab |
| Drug Descriptions |
Vyloy (zolbetuximab) is a monoclonal antibody that binds to the tight junction molecule CLDN18.2, thereby blocking proliferation of tumor cells (PMID: 23900716, PMID: 26811601, PMID: 31240302). Vyloy (zolbetuximab) is FDA-approved for use in combination with fluoropyrimidine- and platinum-containing chemotherapy in patients with CLDN18.2-positive, locally advanced unresectable or metastatic ERBB2 (HER2)-negative gastric or gastroesophageal junction (GEJ) adenocarcinoma (FDA.gov). |
| DrugClasses | CLDN18.2 Antibody 19 |
| CAS Registry Number | 1496553-00-4 |
| NCIT ID | C85475 |
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