Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Drug Name | PF-04518600 |
| Trade Name | |
| Synonyms | PF-8600|PF04518600|Ivuxolimab |
| Drug Descriptions |
PF-04518600 (Ivuxolimab) is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response (Journal of Clinical Oncology 34, no. 15_suppl (May 20 2016) 3079-3079). |
| DrugClasses | OX40 Antibody 15 |
| CAS Registry Number | 2128729-41-7 |
| NCIT ID | C121927 |
| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Avelumab + Azacitidine + PF-04518600 | Avelumab Azacitidine PF-04518600 | 0 | 1 |
| Avelumab + PF-04518600 | Avelumab PF-04518600 | 0 | 4 |
| Avelumab + PF-04518600 + Rituximab | Avelumab PF-04518600 Rituximab | 0 | 1 |
| Avelumab + PF-04518600 + Utomilumab | Avelumab PF-04518600 Utomilumab | 0 | 2 |
| Axitinib + PF-04518600 | Axitinib PF-04518600 | 0 | 1 |
| Azacitidine + PF-04518600 | Azacitidine PF-04518600 | 0 | 1 |
| PF-04518600 | PF-04518600 | 0 | 2 |
| PF-04518600 + Rituximab + Utomilumab | PF-04518600 Rituximab Utomilumab | 0 | 1 |
| PF-04518600 + Utomilumab | PF-04518600 Utomilumab | 0 | 2 |