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Drug Name | PF-04518600 |
Trade Name | |
Synonyms | PF-8600|PF04518600|Ivuxolimab |
Drug Descriptions |
PF-04518600 (Ivuxolimab) is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response (Journal of Clinical Oncology 34, no. 15_suppl (May 20 2016) 3079-3079). |
DrugClasses | OX40 Antibody 14 |
CAS Registry Number | 2128729-41-7 |
NCIT ID | C121927 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Avelumab + Azacitidine + PF-04518600 | Avelumab Azacitidine PF-04518600 | 0 | 1 |
Avelumab + PF-04518600 | Avelumab PF-04518600 | 0 | 4 |
Avelumab + PF-04518600 + Rituximab | Avelumab PF-04518600 Rituximab | 0 | 1 |
Avelumab + PF-04518600 + Utomilumab | Avelumab PF-04518600 Utomilumab | 0 | 2 |
Axitinib + PF-04518600 | Axitinib PF-04518600 | 0 | 1 |
Azacitidine + PF-04518600 | Azacitidine PF-04518600 | 0 | 1 |
PF-04518600 | PF-04518600 | 0 | 2 |
PF-04518600 + Rituximab + Utomilumab | PF-04518600 Rituximab Utomilumab | 0 | 1 |
PF-04518600 + Utomilumab | PF-04518600 Utomilumab | 0 | 2 |