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Drug Name | Trastuzumab Duocarmazine |
Trade Name | |
Synonyms | SYD985|SYD-985|Trastuzumab vc-seco-DUBA|SYD 985|T-Duo |
Drug Descriptions |
Trastuzumab Duocarmazine (SYD985) is an antibody-drug conjugate (ADC) consisting of the Erbb2 (Her2)-targeting antibody trastuzumab bound to a derivative of the cytotoxic drug duocarmycin, which results in increased death of Erbb2 (Her2)-expressing tumor cells (PMID: 27256376). |
DrugClasses | HER2 (ERBB2) Antibody 76 HER2 (ERBB2) Antibody-Drug Conjugate 31 |
CAS Registry Number | 1642152-40-6 |
NCIT ID | C118674 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Niraparib + Trastuzumab Duocarmazine | Niraparib Trastuzumab Duocarmazine | 0 | 1 |
Paclitaxel + Trastuzumab Duocarmazine | Paclitaxel Trastuzumab Duocarmazine | 0 | 1 |
Trastuzumab Duocarmazine | Trastuzumab Duocarmazine | 0 | 3 |