Trastuzumab Duocarmazine
Drug Detail
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| Drug Name | Trastuzumab Duocarmazine |
| Trade Name | |
| Synonyms | SYD985|SYD-985|Trastuzumab vc-seco-DUBA|SYD 985|T-Duo |
| Drug Descriptions |
Trastuzumab Duocarmazine (SYD985) is an antibody-drug conjugate (ADC) consisting of the Erbb2 (Her2)-targeting antibody trastuzumab bound to a derivative of the cytotoxic drug duocarmycin, which results in increased death of Erbb2 (Her2)-expressing tumor cells (PMID: 27256376). |
| DrugClasses | HER2 (ERBB2) Antibody 79 HER2 (ERBB2) Antibody-Drug Conjugate 35 |
| CAS Registry Number | 1642152-40-6 |
| NCIT ID | C118674 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Niraparib + Trastuzumab Duocarmazine | Niraparib Trastuzumab Duocarmazine | 0 | 1 |
| Paclitaxel + Trastuzumab Duocarmazine | Paclitaxel Trastuzumab Duocarmazine | 0 | 1 |
| Trastuzumab Duocarmazine | Trastuzumab Duocarmazine | 0 | 2 |
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