Therapy Detail
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| Therapy Name | Trastuzumab Duocarmazine |
| Synonyms | |
| Therapy Description |
Trastuzumab Duocarmazine (SYD985) is an antibody-drug conjugate (ADC) consisting of the Erbb2 (Her2)-targeting antibody trastuzumab bound to a derivative of the cytotoxic drug duocarmycin, which results in increased death of Erbb2 (Her2)-expressing tumor cells (PMID: 27256376). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Trastuzumab Duocarmazine | SYD985|SYD-985|Trastuzumab vc-seco-DUBA|SYD 985|T-Duo | HER2 (ERBB2) Antibody 76 HER2 (ERBB2) Antibody-Drug Conjugate 31 | Trastuzumab Duocarmazine (SYD985) is an antibody-drug conjugate (ADC) consisting of the Erbb2 (Her2)-targeting antibody trastuzumab bound to a derivative of the cytotoxic drug duocarmycin, which results in increased death of Erbb2 (Her2)-expressing tumor cells (PMID: 27256376). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03262935 | Phase III | Capecitabine + Lapatinib Trastuzumab Duocarmazine Eribulin + Trastuzumab Capecitabine + Trastuzumab Trastuzumab + Vinorelbine | SYD985 vs. Physician's Choice in Participants With HER2-positive Locally Advanced or Metastatic Breast Cancer (TULIP) | Completed | USA | SWE | NLD | ITA | GBR | FRA | ESP | DNK | CAN | BEL | 1 |
| NCT04205630 | Phase II | Trastuzumab Duocarmazine | SYD985 in Patients With HER2-expressing Recurrent, Advanced or Metastatic Endometrial Carcinoma | Completed | USA | POL | 5 |
| NCT01042379 | Phase II | Trilaciclib Trastuzumab Duocarmazine Cyclophosphamide + Doxorubicin Cemiplimab Amcenestrant Abemaciclib + Amcenestrant Carboplatin + Dostarlimab-gxly + HM30181A + Paclitaxel + Trastuzumab Amcenestrant + Letrozole Carboplatin + Dostarlimab-gxly + HM30181A + Paclitaxel Pertuzumab + Trastuzumab + Trilaciclib Paclitaxel + Trastuzumab Pertuzumab + Trastuzumab Cemiplimab + Fianlimab | I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer (I-SPY) | Recruiting | USA | 0 |
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