PAC-1
Drug Detail
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| Drug Name | PAC-1 |
| Trade Name | |
| Synonyms | VO-100 |
| Drug Descriptions |
PAC-1 is a small molecule activator of procaspase 3, which occurs via inhibition of zinc ions, resulting in autoactivation and thus, may lead to apoptotis and anti-tumor activity (PMID: 19281821, PMID: 27297867). |
| DrugClasses | |
| CAS Registry Number | 315183-21-2 |
| NCIT ID | C120318 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Entrectinib + PAC-1 | Entrectinib PAC-1 | 0 | 1 |
| PAC-1 | PAC-1 | 0 | 1 |
| PAC-1 + Temozolomide | PAC-1 Temozolomide | 0 | 1 |
| PAC-1 + Trametinib + Vemurafenib | PAC-1 Trametinib Vemurafenib | 1 | 0 |
| PAC-1 + Vemurafenib | PAC-1 Vemurafenib | 1 | 0 |
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