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| Drug Name | Entrectinib |
| Trade Name | Rozlytrek |
| Synonyms | RXDX-101 |
| Drug Descriptions |
Rozlytrek (entrectinib) inhibits the activity of TrkA/B/C, Ros1 fusion proteins, and Alk, which leads to induction of apoptosis and inhibition of proliferation in cells expressing these kinases (PMID: 27003761). Rozlytrek (entrectinib) is FDA approved for use in patients with ROS1 positive non-small cell lung cancer and in adult and pediatric (1 year and older) patients with solid tumors harboring NTRK fusions without known acquired resistance mutations (FDA.gov). |
| DrugClasses | ALK Inhibitor 32 ROS1 Inhibitor 20 Trk Receptor Inhibitor (Pan) 32 |
| CAS Registry Number | 1108743-60-7 |
| NCIT ID | C114984 |
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