LY2603618
Drug Detail
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| Drug Name | LY2603618 |
| Trade Name | |
| Synonyms | LY-2603618|Rabusertib |
| Drug Descriptions |
Rabusertib (LY2603618) is a small molecule that inhibits CHK1, which may lead to disruption of DNA synthesis, early mitosis, and apoptosis, and may increase tumor cell sensitivity to chemotherapeutics (PMID: 24114124, PMID: 28625637). |
| DrugClasses | CHK1 Inhibitor 18 |
| CAS Registry Number | 911222-45-2 |
| NCIT ID | C81937 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| AMT-562 + LY2603618 | AMT-562 LY2603618 | 0 | 0 |
| Cisplatin + LY2603618 + Pemetrexed Disodium | Cisplatin LY2603618 Pemetrexed Disodium | 0 | 0 |
| Gemcitabine + LY2603618 | Gemcitabine LY2603618 | 0 | 0 |
| LB-100 + LY2603618 | LB-100 LY2603618 | 0 | 0 |
| LY2603618 | LY2603618 | 0 | 0 |
| LY2603618 + Pemetrexed Disodium | LY2603618 Pemetrexed Disodium | 0 | 0 |
| LY2603618 + STP-B | LY2603618 STP-B | 0 | 0 |
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