Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Drug Name LB-100
Trade Name
Synonyms LB100|LB 100
Drug Descriptions

LB-100 is a small molecule that inhibits PP2A activity, resulting in increased sensitivity of tumor cells to DNA damaging agents, including chemotherapy and radiotherapy (PMID: 25376608, PMID: 31935881, PMID: 30679389, PMID: 32342332).

DrugClasses PP2A Inhibitor 2
CAS Registry Number 1632032-53-1
NCIT ID C106430

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Carboplatin + Etoposide + LB-100 Atezolizumab Carboplatin Etoposide LB-100 0 1
Atezolizumab + LB-100 Atezolizumab LB-100 0 2
Ceralasertib + LB-100 Ceralasertib LB-100 0 0
Cisplatin + LB-100 Cisplatin LB-100 2 0
Docetaxel + LB-100 Docetaxel LB-100 0 1
Dostarlimab-gxly + LB-100 Dostarlimab-gxly LB-100 0 1
Doxorubicin + LB-100 Doxorubicin LB-100 0 1
LB-100 LB-100 0 2
LB-100 + LY2603618 LB-100 LY2603618 0 0


Additional content available in CKB BOOST