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Drug Name | MIW815 |
Trade Name | |
Synonyms | ADUS100|ADU-S100|NVP-MIW815 |
Drug Descriptions |
MIW815 (ADUS100) is a synthetic cyclic dinucleotide that acts as an activator for the stimulation of interferon gene signaling (STING1), resulting in T cell differentiation and infiltration of the tumor, thereby possibly resulting in tumor regression (PMID: 28483787, PMID: 31355488). |
DrugClasses | STING1 Agonist 19 |
CAS Registry Number | 1638241-89-0 |
NCIT ID | C125902 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Ipilimumab + MIW815 | Ipilimumab MIW815 | 0 | 1 |
MIW815 | MIW815 | 0 | 1 |
MIW815 + Pembrolizumab | MIW815 Pembrolizumab | 0 | 1 |
MIW815 + Spartalizumab | MIW815 Spartalizumab | 0 | 1 |