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Drug Name GL-ONC1
Trade Name
Synonyms GLV-1h68|Olvimulogene nanivacirepvec|Olvi-Vec
Drug Descriptions

Olvimulogene nanivacirepvec (GL-ONC1) is a genetically engineered light-emitting oncolytic vaccinia virus, which results in viral infection within the cells, thereby possibly inducing cell death and interruption of the cell cycle (PMID: 28679776, PMID: 31567308).

DrugClasses
CAS Registry Number NA
NCIT ID C79833

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Carboplatin + GL-ONC1 + Nab-paclitaxel Atezolizumab Carboplatin GL-ONC1 Nab-paclitaxel 0 1
Atezolizumab + Carboplatin + GL-ONC1 + Paclitaxel Atezolizumab Carboplatin GL-ONC1 Paclitaxel 0 1
Atezolizumab + Carboplatin + GL-ONC1 + Pemetrexed Disodium Atezolizumab Carboplatin GL-ONC1 Pemetrexed Disodium 0 1
Atezolizumab + Cisplatin + GL-ONC1 + Nab-paclitaxel Atezolizumab Cisplatin GL-ONC1 Nab-paclitaxel 0 1
Atezolizumab + Cisplatin + GL-ONC1 + Paclitaxel Atezolizumab Cisplatin GL-ONC1 Paclitaxel 0 1
Atezolizumab + Cisplatin + GL-ONC1 + Pemetrexed Disodium Atezolizumab Cisplatin GL-ONC1 Pemetrexed Disodium 0 1
Bevacizumab + Carboplatin + GL-ONC1 Bevacizumab Carboplatin GL-ONC1 0 1
Bevacizumab + Cisplatin + GL-ONC1 Bevacizumab Cisplatin GL-ONC1 0 1
Carboplatin + Cemiplimab + GL-ONC1 + Nab-paclitaxel Carboplatin Cemiplimab GL-ONC1 Nab-paclitaxel 0 1
Carboplatin + Cemiplimab + GL-ONC1 + Paclitaxel Carboplatin Cemiplimab GL-ONC1 Paclitaxel 0 1
Carboplatin + Cemiplimab + GL-ONC1 + Pemetrexed Disodium Carboplatin Cemiplimab GL-ONC1 Pemetrexed Disodium 0 1
Carboplatin + Durvalumab + GL-ONC1 + Nab-paclitaxel Carboplatin Durvalumab GL-ONC1 Nab-paclitaxel 0 1
Carboplatin + Durvalumab + GL-ONC1 + Paclitaxel Carboplatin Durvalumab GL-ONC1 Paclitaxel 0 1
Carboplatin + Durvalumab + GL-ONC1 + Pemetrexed Disodium Carboplatin Durvalumab GL-ONC1 Pemetrexed Disodium 0 1
Carboplatin + GL-ONC1 + Nab-paclitaxel + Nivolumab Carboplatin GL-ONC1 Nab-paclitaxel Nivolumab 0 1
Carboplatin + GL-ONC1 + Nab-paclitaxel + Pembrolizumab Carboplatin GL-ONC1 Nab-paclitaxel Pembrolizumab 0 1
Carboplatin + GL-ONC1 + Nivolumab + Paclitaxel Carboplatin GL-ONC1 Nivolumab Paclitaxel 0 1
Carboplatin + GL-ONC1 + Nivolumab + Pemetrexed Disodium Carboplatin GL-ONC1 Nivolumab Pemetrexed Disodium 0 1
Carboplatin + GL-ONC1 + Paclitaxel + Pembrolizumab Carboplatin GL-ONC1 Paclitaxel Pembrolizumab 0 1
Carboplatin + GL-ONC1 + Pembrolizumab + Pemetrexed Disodium Carboplatin GL-ONC1 Pembrolizumab Pemetrexed Disodium 0 1
Cemiplimab + Cisplatin + GL-ONC1 + Nab-paclitaxel Cemiplimab Cisplatin GL-ONC1 Nab-paclitaxel 0 1
Cemiplimab + Cisplatin + GL-ONC1 + Paclitaxel Cemiplimab Cisplatin GL-ONC1 Paclitaxel 0 1
Cemiplimab + Cisplatin + GL-ONC1 + Pemetrexed Disodium Cemiplimab Cisplatin GL-ONC1 Pemetrexed Disodium 0 1
Cisplatin + Durvalumab + GL-ONC1 + Nab-paclitaxel Cisplatin Durvalumab GL-ONC1 Nab-paclitaxel 0 1
Cisplatin + Durvalumab + GL-ONC1 + Paclitaxel Cisplatin Durvalumab GL-ONC1 Paclitaxel 0 1
Cisplatin + Durvalumab + GL-ONC1 + Pemetrexed Disodium Cisplatin Durvalumab GL-ONC1 Pemetrexed Disodium 0 1
Cisplatin + GL-ONC1 + Nab-paclitaxel + Nivolumab Cisplatin GL-ONC1 Nab-paclitaxel Nivolumab 0 1
Cisplatin + GL-ONC1 + Nab-paclitaxel + Pembrolizumab Cisplatin GL-ONC1 Nab-paclitaxel Pembrolizumab 0 1
Cisplatin + GL-ONC1 + Nivolumab + Paclitaxel Cisplatin GL-ONC1 Nivolumab Paclitaxel 0 1
Cisplatin + GL-ONC1 + Nivolumab + Pemetrexed Disodium Cisplatin GL-ONC1 Nivolumab Pemetrexed Disodium 0 1
Cisplatin + GL-ONC1 + Paclitaxel + Pembrolizumab Cisplatin GL-ONC1 Paclitaxel Pembrolizumab 0 1
Cisplatin + GL-ONC1 + Pembrolizumab + Pemetrexed Disodium Cisplatin GL-ONC1 Pembrolizumab Pemetrexed Disodium 0 1
Cisplatin + GL-ONC1 + Radiotherapy Cisplatin GL-ONC1 Radiotherapy 0 0
GL-ONC1 GL-ONC1 0 2


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