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Drug Name | Patritumab deruxtecan |
Trade Name | |
Synonyms | U3-1402|HER3-DXd|U3 1402|U31402 |
Drug Descriptions |
Patritumab deruxtecan (U3-1402) is an antibody-drug conjugate (ADC) comprising an ERBB3 (HER3) antibody and Exatecan, which once internalized may result in apoptotic cell death (PMID: 31395690, PMID: 31661465, PMID: 31471314). |
DrugClasses | HER3 (ERBB3) Antibody 23 |
CAS Registry Number | 2227102-46-5 |
NCIT ID | C136987 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Letrozole + Patritumab deruxtecan | Letrozole Patritumab deruxtecan | 0 | 1 |
Olaparib + Patritumab deruxtecan | Olaparib Patritumab deruxtecan | 0 | 1 |
Osimertinib + Patritumab deruxtecan | Osimertinib Patritumab deruxtecan | 0 | 1 |
Patritumab deruxtecan | Patritumab deruxtecan | 0 | 16 |