AK105
Drug Detail
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| Drug Name | AK105 |
| Trade Name | Penpulimab-kcqx |
| Synonyms | AK-105|AK 105|Penpulimab |
| Drug Descriptions |
Penpulimab-kcqx (AK105) is a monoclonal antibody against CD274 (PD-L1) that inhibits binding to the PDCD1 (PD1) receptor, potentially resulting in enhanced anti-tumor immune response (PMID: 29932513). Penpulimab-kcqx (AK105) is FDA-approved for use as monotherapy for adult patients with metastatic non-keratinizing nasopharyngeal carcinoma (NPC) that progressed on prior therapy, and in combination with cisplatin or carboplatin and gemcitabine as first-line treatment for adult patients with recurrent or metastatic non-keratinizing NPC (FDA.gov). |
| DrugClasses | Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 131 |
| CAS Registry Number | 2350298-92-7 |
| NCIT ID | C155879 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| AK105 | AK105 | 0 | 0 |
| AK105 + Anlotinib | AK105 Anlotinib | 0 | 0 |
| AK105 + Carboplatin + Gemcitabine | AK105 Carboplatin Gemcitabine | 0 | 1 |
| AK105 + Cisplatin + Gemcitabine | AK105 Cisplatin Gemcitabine | 0 | 1 |
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