Therapy Detail
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| Therapy Name | AK105 |
| Synonyms | |
| Therapy Description |
Penpulimab-kcqx (AK105) is a monoclonal antibody against CD274 (PD-L1) that inhibits binding to the PDCD1 (PD1) receptor, potentially resulting in enhanced anti-tumor immune response (PMID: 29932513). Penpulimab-kcqx (AK105) is FDA-approved for use as monotherapy for adult patients with metastatic non-keratinizing nasopharyngeal carcinoma (NPC) that progressed on prior therapy, and in combination with cisplatin or carboplatin and gemcitabine as first-line treatment for adult patients with recurrent or metastatic non-keratinizing NPC (FDA.gov). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AK105 | Penpulimab-kcqx | AK-105|AK 105|Penpulimab | Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 134 | Penpulimab-kcqx (AK105) is a monoclonal antibody against CD274 (PD-L1) that inhibits binding to the PDCD1 (PD1) receptor, potentially resulting in enhanced anti-tumor immune response (PMID: 29932513). Penpulimab-kcqx (AK105) is FDA-approved for use as monotherapy for adult patients with metastatic non-keratinizing nasopharyngeal carcinoma (NPC) that progressed on prior therapy, and in combination with cisplatin or carboplatin and gemcitabine as first-line treatment for adult patients with recurrent or metastatic non-keratinizing NPC (FDA.gov). |
Filtering
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- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MSH6 negative | appendix adenocarcinoma | sensitive | AK105 | Guideline | Actionable | Penpulimab-kcqx (AK105) is included in guidelines (category 2A) for patients with advanced or metastatic appendiceal adenocarcinoma with high microsatellite instability (MSI-H) or deficient mismatch repair (dMMR, often defined by the loss of MLH1, PMS2, MSH2, or MSH6 expression by IHC) (NCCN.org). | detail... |
| MLH1 negative | appendix adenocarcinoma | sensitive | AK105 | Guideline | Actionable | Penpulimab-kcqx (AK105) is included in guidelines (category 2A) for patients with advanced or metastatic appendiceal adenocarcinoma with high microsatellite instability (MSI-H) or deficient mismatch repair (dMMR, often defined by the loss of MLH1, PMS2, MSH2, or MSH6 expression by IHC) (NCCN.org). | detail... |
Filtering
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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