IACS-6274
Drug Detail
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| Drug Name | IACS-6274 |
| Trade Name | |
| Synonyms | IACS6274|IACS 6274|IPN60090|IPN-60090|IPN 60090 |
| Drug Descriptions |
IACS-6274 (IPN60090) inhibits glutaminase-1 (GLS1), which prevents the conversion of glutamine to glutamate, potentially resulting in decreased tumor cell proliferation (NCI Drug Dictionary). |
| DrugClasses | Glutaminase Inhibitor 3 |
| CAS Registry Number | 1874231-60-3 |
| NCIT ID | C165612 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Bevacizumab + IACS-6274 + Paclitaxel | Bevacizumab IACS-6274 Paclitaxel | 0 | 1 |
| Capivasertib + IACS-6274 | Capivasertib IACS-6274 | 0 | 1 |
| IACS-6274 | IACS-6274 | 0 | 2 |
| IACS-6274 + Paclitaxel | IACS-6274 Paclitaxel | 0 | 1 |
| IACS-6274 + Pembrolizumab | IACS-6274 Pembrolizumab | 0 | 1 |
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