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Drug Name | NOX-A12 |
Trade Name | |
Synonyms | Olaptesed Pegol|NOX A12|NOXA12 |
Drug Descriptions |
NOX-A12 (olaptesed pegol) binds to CXCL12 and inhibits its interaction with CXCR4 and CXCR7, potentially resulting in increased sensitivity to chemotherapeutic agents, as well as increased infiltration of T-cells into tumors and enhanced anti-tumor immune response in combination with other agents (PMID: 24277076, PMID: 28963140). |
DrugClasses | |
CAS Registry Number | 1390628-22-4 |
NCIT ID | C99379 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Bendamustine + NOX-A12 + Rituximab | Bendamustine NOX-A12 Rituximab | 0 | 0 |
Bevacizumab + NOX-A12 | Bevacizumab NOX-A12 | 0 | 1 |
Nilotinib + NOX-A12 | NOX-A12 Nilotinib | 0 | 0 |
NOX-A12 | NOX-A12 | 0 | 1 |
NOX-A12 + Pembrolizumab | NOX-A12 Pembrolizumab | 0 | 0 |
NOX-A12 + unspecified PD-1 antibody | NOX-A12 unspecified PD-1 antibody | 0 | 0 |