XL092
Drug Detail
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| Drug Name | XL092 |
| Trade Name | |
| Synonyms | XL-092|XL 092|Zanzalintinib |
| Drug Descriptions |
XL092 is a receptor tyrosine kinase inhibitor that targets MET, AXL, VEGFR2, TYRO3, and MER, which potentially leads to decreased tumor cell proliferation and inhibition of tumor growth (PMID: 36399631). |
| DrugClasses | MET Inhibitor 59 VEGFR Inhibitor (Pan) 36 |
| CAS Registry Number | 2367004-54-2 |
| NCIT ID | C161598 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| AB521 + Nivolumab + XL092 | AB521 Nivolumab XL092 | 0 | 1 |
| AB521 + XL092 | AB521 XL092 | 0 | 1 |
| Atezolizumab + XL092 | Atezolizumab XL092 | 0 | 1 |
| Belzutifan + XL092 | Belzutifan XL092 | 0 | 1 |
| Bisphosphonate + XL092 | Bisphosphonate XL092 | 0 | 1 |
| Cemiplimab + XL092 | Cemiplimab XL092 | 0 | 1 |
| Cetuximab + Pembrolizumab + XL092 | Cetuximab Pembrolizumab XL092 | 0 | 1 |
| Denosumab + XL092 | Denosumab XL092 | 0 | 1 |
| Durvalumab + Tremelimumab + XL092 | Durvalumab Tremelimumab XL092 | 0 | 1 |
| Durvalumab + XL092 | Durvalumab XL092 | 0 | 1 |
| Eribulin + XL092 | Eribulin XL092 | 0 | 1 |
| Etoposide + XL092 | Etoposide XL092 | 0 | 1 |
| Ipilimumab + Nivolumab + XL092 | Ipilimumab Nivolumab XL092 | 0 | 2 |
| Nivolumab + NKTR-214 + XL092 | NKTR-214 Nivolumab XL092 | 0 | 1 |
| Nivolumab + XL092 | Nivolumab XL092 | 0 | 3 |
| Paclitaxel + XL092 | Paclitaxel XL092 | 0 | 1 |
| Pembrolizumab + XL092 | Pembrolizumab XL092 | 0 | 1 |
| XL092 | XL092 | 0 | 12 |
| XL092 + Zoledronic acid | XL092 Zoledronic acid | 0 | 1 |
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