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Drug Name XL092
Trade Name
Synonyms XL-092|XL 092|Zanzalintinib
Drug Descriptions

XL092 is a receptor tyrosine kinase inhibitor that targets MET, AXL, VEGFR2, TYRO3, and MER, which potentially leads to decreased tumor cell proliferation and inhibition of tumor growth (PMID: 36399631).

DrugClasses MET Inhibitor 59 VEGFR Inhibitor (Pan) 36
CAS Registry Number 2367004-54-2
NCIT ID C161598

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AB521 + Nivolumab + XL092 AB521 Nivolumab XL092 0 1
AB521 + XL092 AB521 XL092 0 1
Atezolizumab + XL092 Atezolizumab XL092 0 1
Durvalumab + Tremelimumab + XL092 Durvalumab Tremelimumab XL092 0 1
Ipilimumab + Nivolumab + XL092 Ipilimumab Nivolumab XL092 0 1
Nivolumab + NKTR-214 + XL092 NKTR-214 Nivolumab XL092 0 1
Nivolumab + XL092 Nivolumab XL092 0 2
Pembrolizumab + XL092 Pembrolizumab XL092 0 1
XL092 XL092 0 4


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