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Drug Name | BI 1701963 |
Trade Name | |
Synonyms | BI1701963|BI-1701963 |
Drug Descriptions |
BI 1701963 binds to SOS1 thus prevents SOS1 interaction with Kras-GDP, resulting in inhibition of Kras downstream signaling and potential inhibition of tumor cell growth (AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Oct 2019, Abstract PL06-01). |
DrugClasses | SOS1 Inhibitor 16 |
CAS Registry Number | NA |
NCIT ID | C166138 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Adagrasib + BI 1701963 | Adagrasib BI 1701963 | 0 | 1 |
BI 1701963 | BI 1701963 | 0 | 1 |
BI 1701963 + BI 1823911 | BI 1701963 BI 1823911 | 0 | 1 |
BI 1701963 + BI 3706674 | BI 1701963 BI 3706674 | 0 | 0 |
BI 1701963 + Sotorasib | BI 1701963 Sotorasib | 0 | 1 |
BI 1701963 + Trametinib | BI 1701963 Trametinib | 0 | 1 |