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Gene TET2
Variant H924R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TET2 H924R does not lie within any known functional domains of the Tet2 protein (UniProt.org). H924R has been identified in sequencing studies (PMID: 26984174), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

TET2 mutant TET2 H924R

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Transcript NM_001127208.3
gDNA chr4:g.105236713A>G
cDNA c.2771A>G
Protein p.H924R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_017628.4 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
NM_001127208 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
XM_017008319.1 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
XM_024454102.1 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
XM_005263082.3 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
XM_005263082 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
XM_005263082.4 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
XM_006714242.3 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
XM_047415842.1 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
XM_047415843.1 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
XM_006714242 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
XM_047415839.1 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
NM_017628.4 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
XM_047415840.1 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
XM_047415841.1 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
XM_017008319 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
XM_024454103.1 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
NM_001127208.2 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
XM_017008319.2 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
NM_017628 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
XM_006714242.4 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
XM_024454102.2 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
XM_024454103.2 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38
NM_001127208.3 chr4:g.105236713A>G c.2771A>G p.H924R RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TET2 mutant myelofibrosis not applicable N/A Guideline Diagnostic TET2 mutations aid in the diagnosis of primary myelofibrosis in the absence of JAK2, CALR, or MPL mutations (NCCN.org). detail...
TET2 mutant acute myeloid leukemia predicted - sensitive Azacitidine Phase I Actionable In a retrospective analysis, presence of a TET2 mutation correlated with higher overall response rate (ORR) in patients with myelodysplastic syndrome and acute myeloid leukemia following treatment with Vidaza (azacitidine), with an ORR of 85% (11/3) in TET2-mutated patients, compared to 47% (34/47) in patients with wild-type TET2, but did not correlate with overall survival (PMID: 21494260). 21494260
TET2 mutant acute myeloid leukemia not applicable N/A Clinical Study Prognostic In multiple clinical studies, including a meta-analysis, TET2 mutations were associated with shorter overall survival in patients with acute myeloid leukemia (PMID: 24524305, PMID: 25412851, PMID: 24994606). 24524305 25412851 24994606
TET2 mutant acute myeloid leukemia sensitive Olaparib Preclinical - Patient cell culture Actionable In a preclinical study, Lynparza (olaparib) treatment inhibited colony formation in patient-derived acute myeloid leukemia cells harboring a TET2 mutation along with FLT3-ITD and NPM1 mutation in culture (PMID: 34215619). 34215619
TET2 mutant angioimmunoblastic T-cell lymphoma not applicable N/A Guideline Diagnostic TET2 mutations aid in the diagnosis of angioimmunoblastic T-cell lymphoma (NCCN.org). detail...