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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Showing 1 to 48 of 48 entries

Gene	Variant	Impact	Protein Effect	Variant Description
TET2	K67fs	frameshift	loss of function - predicted	TET2 K67fs results in a change in the amino acid sequence of the Tet2 protein beginning at aa 67 of 2002 (UniProt.org). K67fs has not been characterized however, due to the effects of other truncation mutations downstream of K67 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	D162fs	frameshift	loss of function - predicted	TET2 D162fs results in a change in the amino acid sequence of the Tet2 protein beginning at aa 162 of 2002, likely resulting in premature truncation of the functional protein (UniProt.org). D162fs has not been characterized, however, due to the effects of other truncation mutations downstream of D162 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	H222Tfs*3	frameshift	loss of function - predicted	TET2 H222Tfs3 indicates a shift in the reading frame starting at amino acid 222 and terminating 3 residues downstream causing a premature truncation of the 2002 amino acid Tet2 protein (UniProt.org). H222Tfs3 has not been characterized however, due to the effects of other truncation mutations downstream of H222 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	I249fs	frameshift	loss of function - predicted	TET2 I249fs results in a change in the amino acid sequence of the Tet2 protein beginning at aa 249 of 2002, likely resulting in premature truncation of the functional protein (UniProt.org). I249fs has not been characterized, however, due to the effects of other truncation mutations downstream of I249 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	Q317fs	frameshift	loss of function - predicted	TET2 Q317fs results in a change in the amino acid sequence of the Tet2 protein beginning at aa 317 of 2002, likely resulting in premature truncation of the functional protein (UniProt.org). Q317fs has not been characterized, however, due to the effects of other truncation mutations downstream of Q317 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	E320*	nonsense	loss of function - predicted	TET2 E320* results in a premature truncation of the Tet2 protein at amino acid 320 of 2002 (UniProt.org). E320* has not been characterized however, due to the effects of other truncation mutations downstream of E320 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	S354*	nonsense	loss of function - predicted	TET2 S354* results in a premature truncation of the Tet2 protein at amino acid 354 of 2002 (UniProt.org). S354* has not been characterized however, due to the effects of other truncation mutations downstream of S354 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	S393Lfs*34	frameshift	loss of function - predicted	TET2 S393Lfs34 indicates a shift in the reading frame starting at amino acid 393 and terminating 34 residues downstream causing a premature truncation of the 2002 amino acid Tet2 protein (UniProt.org). S393Lfs34 has not been characterized however, due to the effects of other truncation mutations downstream of S393 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	K450*	nonsense	loss of function - predicted	TET2 K450* results in a premature truncation of the Tet2 protein at amino acid 450 of 2002 (UniProt.org). K450* has not been characterized however, due to the effects of other truncation mutations downstream of K450 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	R506*	nonsense	loss of function - predicted	TET2 R506* results in a premature truncation of the Tet2 protein at amino acid 506 of 2002 (UniProt.org). R506* results in a loss of 5-hydroxymethylcytosine (5hmc) formation in cultured cells (PMID: 24994606), and therefore, is predicted to lead to a loss of Tet2 protein function.
TET2	D545Tfs*10	frameshift	loss of function - predicted	TET2 D545Tfs10 indicates a shift in the reading frame starting at amino acid 545 and terminating 10 residues downstream causing a premature truncation of the 2002 amino acid Tet2 protein (UniProt.org). D545Tfs10 has not been characterized however, due to the effects of other truncation mutations downstream of D545 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	R550*	nonsense	loss of function - predicted	TET2 R550* results in a premature truncation of the Tet2 protein at amino acid 550 of 2002 (UniProt.org). R550* has not been characterized however, due to the effects of other truncation mutations downstream of R550 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	Q591*	nonsense	loss of function - predicted	TET2 Q591* results in a premature truncation of the Tet2 protein at amino acid 591 of 2002 (UniProt.org). Q591* has not been characterized however, due to the effects of other truncation mutations downstream of Q591 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	Q642*	nonsense	loss of function - predicted	TET2 Q642* results in a premature truncation of the Tet2 protein at amino acid 642 of 2002 (UniProt.org). Q642* has not been characterized however, due to the effects of other truncation mutations downstream of Q642 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	Q652*	nonsense	loss of function - predicted	TET2 Q652* results in a premature truncation of the Tet2 protein at amino acid 652 of 2002 (UniProt.org). Q652* has not been characterized however, due to the effects of other truncation mutations downstream of Q652 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	Q690*	nonsense	loss of function - predicted	TET2 Q690* results in a premature truncation of the Tet2 protein at amino acid 690 of 2002 (UniProt.org). Q690* has not been characterized however, due to the effects of other truncation mutations downstream of Q690 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	Q701*	nonsense	loss of function - predicted	TET2 Q701* results in a premature truncation of the Tet2 protein at amino acid 701 of 2002 (UniProt.org). Q701* has not been characterized however, due to the effects of other truncation mutations downstream of Q701 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	Q742*	nonsense	loss of function - predicted	TET2 Q742* results in a premature truncation of the Tet2 protein at amino acid 742 of 2002 (UniProt.org). Q742* has not been characterized however, due to the effects of other truncation mutations downstream of Q742 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	C784fs	frameshift	loss of function - predicted	TET2 C784fs results in a change in the amino acid sequence of the Tet2 protein beginning at aa 784 of 2002, likely resulting in premature truncation of the functional protein (UniProt.org). C784fs has not been characterized however, due to the effects of other truncation mutations downstream of C784 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	S792*	nonsense	loss of function - predicted	TET2 S792* results in a premature truncation of the Tet2 protein at amino acid 792 of 2002 (UniProt.org). S792* has not been characterized however, due to the effects of other truncation mutations downstream of S792 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	I812fs	frameshift	loss of function - predicted	TET2 I812fs results in a change in the amino acid sequence of the Tet2 protein beginning at aa 812 of 2002, likely resulting in premature truncation of the functional protein (UniProt.org). I812fs has not been characterized however, due to the effects of other truncation mutations downstream of I812 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	S833Ffs*8	frameshift	loss of function - predicted	TET2 S833Ffs8 indicates a shift in the reading frame starting at amino acid 833 and terminating 8 residues downstream causing a premature truncation of the 2002 amino acid Tet2 protein (UniProt.org). S833Ffs8 has not been characterized however, due to the effects of other truncation mutations downstream of S833 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	S835*	nonsense	loss of function - predicted	TET2 S835* results in a premature truncation of the Tet2 protein at amino acid 835 of 2002 (UniProt.org). S835* has not been characterized however, due to the effects of other truncation mutations downstream of S835 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	Q876*	nonsense	loss of function - predicted	TET2 Q876* results in a premature truncation of the Tet2 protein at amino acid 876 of 2002 (UniProt.org). Q876* has not been characterized however, due to the effects of other truncation mutations downstream of Q876 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	Q891fs	frameshift	loss of function - predicted	TET2 Q891fs results in a change in the amino acid sequence of the Tet2 protein beginning at aa 891 of 2002, likely resulting in premature truncation of the functional protein (UniProt.org). Q891fs has not been characterized however, due to the effects of other truncation mutations downstream of Q891 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	Q916*	nonsense	loss of function - predicted	TET2 Q916* results in a premature truncation of the Tet2 protein at amino acid 916 of 2002 (UniProt.org). Q916* has not been characterized however, due to the effects of other truncation mutations downstream of Q916 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	P929Lfs*24	frameshift	loss of function - predicted	TET2 P929Lfs24 indicates a shift in the reading frame starting at amino acid 929 and terminating 24 residues downstream causing a premature truncation of the 2002 amino acid Tet2 protein (UniProt.org). P929Lfs24 has not been characterized however, due to the effects of other truncation mutations downstream of P929 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	Q958Rfs*49	frameshift	loss of function - predicted	TET2 Q958Rfs49 indicates a shift in the reading frame starting at amino acid 958 and terminating 49 residues downstream causing a premature truncation of the 2002 amino acid Tet2 protein (UniProt.org). Q958Rfs49 has not been characterized however, due to the effects of other truncation mutations downstream of Q958 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	V1006Gfs*3	frameshift	loss of function - predicted	TET2 V1006Gfs3 indicates a shift in the reading frame starting at amino acid 1006 and terminating 3 residues downstream causing a premature truncation of the 2002 amino acid Tet2 protein (UniProt.org). V1006Gfs3 has not been characterized however, due to the effects of other truncation mutations downstream of V1006 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	T1063Nfs*5	frameshift	loss of function - predicted	TET2 T1063Nfs5 indicates a shift in the reading frame starting at amino acid 1063 and terminating 5 residues downstream causing a premature truncation of the 2002 amino acid Tet2 protein (UniProt.org). T1063Nfs5 has not been characterized however, due to the effects of other truncation mutations downstream of T1063 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	R1067*	nonsense	loss of function - predicted	TET2 R1067* results in a premature truncation of the Tet2 protein at amino acid 1067 of 2002 (UniProt.org). R1067* has not been characterized however, due to the effects of other truncation mutations downstream of R1067 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	D1143fs	frameshift	loss of function - predicted	TET2 D1143fs results in a change in the amino acid sequence of the Tet2 protein beginning at aa 1143 of 2002, likely resulting in premature truncation of the functional protein (UniProt.org). D1143fs has not been characterized however, due to the effects of other truncation mutations downstream of D1143 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	K1171fs	frameshift	loss of function - predicted	TET2 K1171fs results in a change in the amino acid sequence of the Tet2 protein beginning at aa 1171 of 2002, likely resulting in premature truncation of the functional protein (UniProt.org). K1171fs has not been characterized however, due to the effects of other truncation mutations downstream of K1171 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	R1179Efs*47	frameshift	loss of function - predicted	TET2 R1179Efs47 indicates a shift in the reading frame starting at amino acid 1179 and terminating 47 residues downstream causing a premature truncation of the 2002 amino acid Tet2 protein (UniProt.org). R1179Efs47 has not been characterized however, due to the effects of other truncation mutations downstream of R1179 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	Q1191*	nonsense	loss of function - predicted	TET2 Q1191* results in a premature truncation of the Tet2 protein at amino acid 1191 of 2002 (UniProt.org). Q1191* has not been characterized however, due to the effects of other truncation mutations downstream of Q1191 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	W1198*	nonsense	loss of function - predicted	TET2 W1198* results in a premature truncation of the Tet2 protein at amino acid 1198 of 2002 (UniProt.org). W1198* has not been characterized however, due to the effects of other truncation mutations downstream of W1198 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	E1323*	nonsense	loss of function - predicted	TET2 E1323* results in a premature truncation of the Tet2 protein at amino acid 1323 of 2002 (UniProt.org). E1323* has not been characterized however, due to the effects of other truncation mutations downstream of E1323 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	S1369*	nonsense	loss of function - predicted	TET2 S1369* results in a premature truncation of the Tet2 protein at amino acid 1369 of 2002 (UniProt.org). S1369* has not been characterized however, due to the effects of other truncation mutations downstream of S1369 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	Q1389*	nonsense	loss of function - predicted	TET2 Q1389* results in a premature truncation of the Tet2 protein at amino acid 1389 of 2002 (UniProt.org). Q1389* has not been characterized however, due to the effects of other truncation mutations downstream of Q1389 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	R1404*	nonsense	loss of function - predicted	TET2 R1404* results in a premature truncation of the Tet2 protein at amino acid 1404 of 2002 (UniProt.org). R1404* has not been characterized however, due to the effects of other truncation mutations downstream of R1404 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	Q1414*	nonsense	loss of function - predicted	TET2 Q1414* results in a premature truncation of the Tet2 protein at amino acid 1414 of 2002 (UniProt.org). Q1414* has not been characterized however, due to the effects of other truncation mutations downstream of Q1414 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	R1440fs	frameshift	loss of function - predicted	TET2 R1440fs results in a change in the amino acid sequence of the Tet2 protein beginning at aa 1440 of 2002, likely resulting in premature truncation of the functional protein (UniProt.org). R1440fs has not been characterized however, due to the effects of other truncation mutations downstream of R1440 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	R1452*	nonsense	loss of function - predicted	TET2 R1452* results in a premature truncation of the Tet2 protein at amino acid 1452 of 2002 (UniProt.org). R1452* has not been characterized however, due to the effects of other truncation mutations downstream of R1452 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	R1465*	nonsense	loss of function - predicted	TET2 R1465* results in a premature truncation of the Tet2 protein at amino acid 1465 of 2002 (UniProt.org). R1465* has not been characterized however, due to the effects of other truncation mutations downstream of R1465 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	E1477*	nonsense	loss of function - predicted	TET2 E1477* results in a premature truncation of the Tet2 protein at amino acid 1477 of 2002 (UniProt.org). E1477* has not been characterized however, due to the effects of other truncation mutations downstream of E1477 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	R1516*	nonsense	loss of function - predicted	TET2 R1516* results in a premature truncation of the Tet2 protein at amino acid 1516 of 2002 (UniProt.org). R1516* has not been characterized however, due to the effects of other truncation mutations downstream of R1516 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	C1642Wfs*49	frameshift	loss of function - predicted	TET2 C1642Wfs49 indicates a shift in the reading frame starting at amino acid 1642 and terminating 49 residues downstream causing a premature truncation of the 2002 amino acid Tet2 protein (UniProt.org). C1642Wfs49 has not been characterized however, due to the effects of other truncation mutations downstream of C1642 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
TET2	S1758*	nonsense	loss of function - predicted	TET2 S1758* results in a premature truncation of the Tet2 protein at amino acid 1758 of 2002 (UniProt.org). S1758* results in a loss of 5-hydroxymethylcytosine (5hmc) formation in cultured cells (PMID: 24994606), and therefore, is predicted to lead to a loss of Tet2 protein function.

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
TET2 mutant	acute myeloid leukemia	not applicable	N/A	Clinical Study	Prognostic	In multiple clinical studies, including a meta-analysis, TET2 mutations were associated with shorter overall survival in patients with acute myeloid leukemia (PMID: 24524305, PMID: 25412851, PMID: 24994606).	24524305 25412851 24994606

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