Gene Variant Detail

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Gene ATM
Variant del
Impact List deletion
Protein Effect loss of function
Gene Variant Descriptions ATM del indicates a deletion of the ATM gene.
Associated Drug Resistance
Category Variants Paths

ATM mutant ATM inact mut ATM del

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM del lung non-small cell carcinoma sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, Lynparza (olaparib) treatment inhibited viability of ATM knockout non-small cell lung carcinoma cells in culture (PMID: 31699977). 31699977
ATM del prostate cancer no benefit Olaparib Preclinical - Cell culture Actionable In a preclinical study, ATM-deficient prostate cancer cell lines did not respond to treatment with Lynparza (olaparib) in culture (PMID: 32127357). 32127357
ATM del head and neck cancer sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, Lynparza (olaparib) treatment induced genomic instability, cell cycle arrest, and inhibited viability of an ATM knockout head and neck cancer cell line in culture (PMID: 31699977). 31699977
ATM del prostate cancer no benefit Rucaparib Preclinical - Cell culture Actionable In a preclinical study, ATM-deficient prostate cancer cell lines did not respond to treatment with Rubraca (rucaparib) in culture (PMID: 32127357). 32127357
ATM del prostate cancer sensitive Berzosertib Preclinical - Cell culture Actionable In a preclinical study, ATM-deficient prostate cancer cell lines were sensitive to treatment with Berzosertib (VX-970) in culture, demonstrating inhibition of cell growth (PMID: 32127357). 32127357
ATM del lung non-small cell carcinoma sensitive AZD7648 Preclinical - Cell culture Actionable In a preclinical study, AZD7648 treatment inhibited viability of ATM knockout non-small cell lung carcinoma cells in culture (PMID: 31699977). 31699977
ATM del head and neck cancer sensitive AZD7648 Preclinical - Cell culture Actionable In a preclinical study, AZD7648 treatment induced genomic instability, cell cycle arrest, and inhibited viability of an ATM knockout head and neck cancer cell line in culture (PMID: 31699977). 31699977
ATM del lung non-small cell carcinoma sensitive AZD7648 + Olaparib Preclinical - Cell culture Actionable In a preclinical study, AZD7648 treatment increased sensitivity to Lynparza (olaparib), inducing cell cycle arrest and inhibiting viability of ATM knockout non-small cell lung carcinoma cells in culture (PMID: 31699977). 31699977
ATM del head and neck cancer sensitive AZD7648 + Olaparib Preclinical - Cell line xenograft Actionable In a preclinical study, AZD7648 treatment increased sensitivity to Lynparza (olaparib), resulting in inhibition of Dna-pk phosphorylation, reduced cell viability, genomic instability, cell cycle arrest, and apoptosis in a head and neck cancer cell line with ATM deletion in culture, and inhibition of tumor growth and complete tumor regression in a cell line xenograft model (PMID: 31699977). 31699977
ATM del prostate cancer sensitive PLX038 Preclinical - Cell line xenograft Actionable In a preclinical study, PLX038 resulted in inhibition of tumor growth and increased event-free survival in a cell line xenograft model of prostate cancer harboring ATM deletion (PMID: 35999657). 35999657
ATM del colorectal cancer sensitive E7820 Preclinical - Cell culture Actionable In a preclinical study, E7820 inhibited viability of a colorectal cancer cell line with knockout of ATM in culture (PMID: 38789724). 38789724
ATM del colorectal cancer sensitive Indisulam Preclinical - Cell culture Actionable In a preclinical study, Indisulam (E7070) inhibited viability of a colorectal cancer cell line with knockout of ATM in culture (PMID: 38789724). 38789724
ATM del prostate cancer sensitive PLX038 + Talazoparib Preclinical - Cell line xenograft Actionable In a preclinical study, PLX038 and Talzenna (talazoparib) combination treatment resulted in synergistic inhibition of tumor growth and increased event-free survival in a cell line xenograft model of prostate cancer harboring ATM deletion (PMID: 35999657). 35999657
ATM del colon cancer predicted - sensitive Radiotherapy + RP-3500 Preclinical Actionable In a preclinical study, RP-3500 and radiotherapy synergistically inhibited growth of an ATM knockout mouse colon cancer cell line in culture and improved survival in a mouse syngeneic model, with complete responses achieved in 7 out of 8 ATM knockout mice compared to 1 out of 8 ATM wild-type mice (Cancer Res (2024) 84 (1_Supplement): A002). detail...
ATM del breast cancer predicted - sensitive Radiotherapy + RP-3500 Preclinical Actionable In a preclinical study, RP-3500 and radiotherapy synergistically inhibited growth of an ATM knockout mouse breast cancer cell line in culture, delayed tumor growth (p<0.001), and improved survival (20% vs 0% alive at 150 days) in a mouse syngeneic model (Cancer Res (2024) 84 (1_Supplement): A002). detail...