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Gene BRAF
Variant L597X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF L597X indicates any BRAF missense mutation that results in replacement of the leucine (L) at amino acid 597 by a different amino acid.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF L597X

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Transcript NM_004333.6
gDNA chr7:g.140753344_140753346
cDNA c.1789_1791
Protein p.L597
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333.6 chr7:g.140753344_140753346 c.1789_1791 p.L597 RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753344_140753346 c.1789_1791 p.L597 RefSeq GRCh38/hg38
NM_001378472.1 chr7:g.140749332_140749334 c.1789_1791 p.L597 RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753344_140753346 c.1789_1791 p.L597 RefSeq GRCh38/hg38
NM_001378473.1 chr7:g.140749332_140749334 c.1789_1791 p.L597 RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753344_140753346 c.1789_1791 p.L597 RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753344_140753346 c.1789_1791 p.L597 RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753344_140753346 c.1789_1791 p.L597 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF L597X melanoma sensitive Trametinib Guideline Actionable Mekinist (trametinib) is included in guidelines as second-line therapy for metastatic or unresectable cutaneous melanoma patients with BRAF L597 mutations (NCCN.org). detail...