NRAS G12D
Gene Variant Detail

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Gene NRAS
Variant G12D
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions NRAS G12D is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12D confers a loss of function on Nras protein as indicated by decreased intrinsic GTPase activity, reduced sensitivity to GTPase-activating proteins, leading to accumulation of GTP-bound Nras, activation of downstream signaling, and transformation of cultured cells (PMID: 19075190, PMID: 25252692).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G12D

NRAS mutant NRAS exon2 NRAS G12X NRAS G12D

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Transcript NM_002524.5
gDNA chr1:g.114716126C>T
cDNA c.35G>A
Protein p.G12D
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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