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| Gene | EML4 ALK |
| Variant | EML4 - ALK |
| Impact List | fusion |
| Protein Effect | gain of function |
| Gene Variant Descriptions | EML4-ALK results from the fusion of EML4 and ALK, resulting in constitutive kinase activity, transformation in cultured cells, and tumor formation in mouse models (PMID: 19064915, PMID: 17625570, PMID: 35138907). EML4-ALK fusions have been associated with non-small cell lung cancer (PMID: 26755435). |
| Associated Drug Resistance | |
| Category Variants Paths |
ALK mutant ALK act mut EML4 - ALK ALK mutant ALK rearrange ALK fusion EML4 - ALK EML4 mutant EML4 fusion EML4 - ALK |